Research Highlights

December 9, 2019 Research Highlights

Methodology Consultation Success Story: Dr. Ashish Premkumar

The incidence of neonatal abstinence syndrome (NAS), also known as neonatal withdrawal syndrome, increased nationally from 3.4 per 1000 hospital births in 2009 to 5.8 in 2012. Recent estimates of NAS cost $1.5 billion dollars with the majority of the financial burden falling to state Medicaid programs. However, pregnancy offers a unique opportunity for women with […]

October 31, 2019 Research Highlights

USPSTF and CDC Recommend Expanded HCV Testing for All US Adults

The US Preventive Services Task Force (USPSTF) released a draft recommendation for hepatitis C (HCV) antibody and RNA screening in all adults ages 18 to 79. This is a departure from their current 2013 recommendation of risk-based screening, including people who inject drugs (PWID), and one-time screening in baby boomers born between 1945 and 1965.  The recommendation […]

September 6, 2019 Research Highlights

Increased number of children entering the foster care due to parental drug use

In a recent study published in JAMA Pediatrics, CHERISH Pilot Grant Recipient Angelica Meinhofer examined national trends in foster care entries attributable to parental drug use between 2000 and 2017. There were approximately 5 million foster care entries between 2000 and 2017, 23.38% percent of which were attributable to parental drug use. Moreover, the number of […]

July 16, 2019 Research Highlights

Care Integration of Hepatitis C and Opioid Use Disorder Treatment is Cost-Effective and Improves Health Outcomes

People who inject drugs (PWID) often become infected with HIV and hepatitis C virus (HCV). While hepatitis C can be successfully treated with medication, care is often fragmented and rarely integrated within one program or setting. Two recent studies by CHERISH researchers modeled economic and health outcomes for PWID and found evidence of synergistic benefits […]

July 10, 2019 Research Highlights

No Safe Dose for That First Opioid Prescription

LDI Senior Fellows Zack Meisel, Benjamin Sun, and colleagues have a striking and sobering chart in a recent Annals of Emergency Medicine article on initial opioid prescriptions in the emergency department. They tracked how many “opioid-naïve” patients (i.e., those without a record of opioid use in the previous year) had persistent or high-risk opioid prescription use in the subsequent […]

June 3, 2019 Research Highlights

Buprenorphine for Opioid Use Disorder Lowers Overdose Risk in Commercially Insured Individuals

“Medications for opioid use disorder saves lives.” That’s the title and conclusion of a recent report by the National Academies of Sciences, Engineering and Medicine, based on a review of the scientific evidence. In a new study in Drug and Alcohol Dependence, CHERISH investigators Jake Morgan, Bruce Schackman and Benjamin Linas add to this evidence base by […]

May 14, 2019 Research Highlights

Neonatal Abstinence Syndrome and the Opioid Crisis: Paying Attention to Social Context

As you likely continue to read in your local news or experience in your community, the United States is in the midst of a deadly drug overdose and addiction crisis. In fact, overdoses claimed the lives of 70,000 individuals in 2017—more than two-thirds of those overdoses were linked to opioids. While drug overdoses disproportionately affect young adults, there […]

April 5, 2019 Research Highlights

Using the 340B Drug Pricing Program to Support Primary Care-Based Hepatitis C Treatment in a Safety-Net Hospital Patient-Centered Medical Home

Over 2 million people in the US had chronic hepatitis C (HCV) infection during 2013- 2016, and HCV remains a leading cause of morbidity and mortality in the United States. Expanding HCV treatment in primary care would improve treatment access and follow-up but is resource intensive, requiring significant staff support. Using a budget impact analysis, a new study […]

March 15, 2019 Research Highlights

Starting Opioid Use Disorder Treatment in the Emergency Department: Physician-reported barriers and facilitators

Every day, we hear about the staggering toll of the opioid overdose crisis. This is particularly salient in Philadelphia, which has one of the highest overdose death rates among major U.S. cities. Despite effective medications for opioid use disorder, such as buprenorphine and methadone, few people receive treatment. The ongoing challenge is to expand access to these lifesaving treatments […]

March 7, 2019 Research Highlights

Strengthening Partnerships Between Substance Use Researchers and Policy Makers

Comprehensive evidence-based policy is crucial in combatting the substance use crisis. CHERISH Investigators from the University of Pennsylvania Leonard Davis Institute Zachary Meisel, Julia Mitchell, Daniel Polsky and Janet Weiner published a new study in Substance Abuse Treatment Prevention and Policy that describes how eighteen policy makers involved in the delivery of health services engage with substance […]

February 21, 2019 Research Highlights

Naloxone Sales Likely to Increase after Switch to Over-the-Counter Status

Naloxone is an opioid antagonist rescue medication that reverses the effects of an opioid overdose, and thus a critical tool to prevent fatal opioid overdoses. CHERISH Investigators Drs. Sean Murphy, Jake Morgan, and Bruce Schackman, and CHERISH staff member Philip Jeng, MS predicted pharmacy sales following conversion of naloxone to over-the-counter (OTC) in a new […]

February 12, 2019 Research Highlights

Opioids and Hepatitis C: How OxyContin Fed a New Epidemic

Purdue Pharma’s 2010 reformulation of OxyContin as an abuse-resistant pill was supposed to be a breakthrough in battling the burgeoning opioid epidemic. Purdue executives and policymakers touted the reformulation as a way to dampen the supply of abusable drugs, thereby reducing opioid addiction and death. Nearly a decade later, it appears that the policy had several serious […]

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