Medication for Opioid Use Disorder

In the U.S., as few as 1 in 8 individuals who inject drugs receives the necessary care to prevent or treat their substance use and related health conditions like wound infections, hepatitis C virus (HCV), or HIV. While syringe services programs (SSP) offer non-stigmatizing and low-barrier care, such as needle exchange, on-site HCV and HIV […]

State laws that ban insurance prior authorization for buprenorphine—a leading medication for opioid use disorder—may not help more patients stay in treatment for the recommended minimum of 180 days, Weill Cornell Medicine researchers report. Though prescription buprenorphine can be a life-saving treatment that relieves opioid cravings and withdrawal symptoms, adherence to the medication is low. […]

There is a growing body of research illustrating a movement to remove prior authorization for medications for opioid use disorder (MOUD). Prior authorization requires providers to request approval from an insurer before providing a medication or service. This process is historically enforced for a wide range of medications, including certain MOUD, and has been found […]

On September 29, 2025, the Justice Community Overdose Innovation Network (JCOIN) kicked off Phase II of its new five-year cycle that represents an estimated $33 million in research investments in 2025. Awarded by the National Institute on Drug Abuse (NIDA) as part of the NIH HEAL Initiative, the investments help establish clinical research hubs and […]

Buprenorphine, when prescribed in the emergency department (ED), increases the chances for treatment engagement and retention among patients with opioid use disorder (OUD). The patient uptake and clinical administration of ED-initiated buprenorphine for OUD, however, has been slow despite evidence of its effectiveness. Implementation facilitation (IF), a strategy that leverages external facilitators and a local […]

Lead author Hana Zwick, a research data analyst at the Syndemics Lab, and colleagues published a new simulation modeling study in JAMA Network Open to understand the public health and economic outcomes of strategies that arrest, disperse, or house people who live in encampments and experience high-risk opioid use compared to the encampment status quo. […]

Methadone is known as the gold standard treatment for opioid use disorder, with some experts calling it a “miracle drug” for its effectiveness in blocking the effects of other opioids and preventing withdrawal. Since 1972, its use has been limited to specialized opioid treatment programs, with patients required to travel to a clinic for daily dosing. This […]

The Syndemics Lab, led by CHERISH Population Data & Modeling Core Director Benjamin Linas, uses simulation models to investigate population-level outcomes, costs, and cost-effectiveness of interventions and care delivery models to treat HIV, hepatitis C virus (HCV), and substance use disorder. In addition to their core research, the Boston-based team collaborates with real-world decision-makers to […]

Overdose is the leading cause of death among people with opioid use disorder (OUD) who are experiencing homelessness. Innovative care models that meet this population outside of office-based settings can improve access to buprenorphine, a medication for treating OUD, and avert fatal overdoses. In this study, Avik Chatterjee, lead author and addiction specialist at Boston […]

In the last eight years, emergency departments (EDs) have seen an influx of visits related to opioid use disorder (OUD). For the same reason, researchers have been citing EDs to be a critical setting and reachable moment for initiating OUD medications, the gold standard of care. Buprenorphine is advantageous as a low-barrier OUD treatment compared […]

CHERISH is excited to welcome a new pilot grant cohort for the 10th year. Spearheaded by CHERISH Pilot Grant Program Director Brandon Aden, the program is designed to help researchers gain familiarity with health economic evaluations, apply related methodologies to their pilot research, and build out the next stage of their careers. This year, CHERISH […]

Substance use disorders (SUD), and especially opioid use disorder (OUD), are prevalent within the criminal-legal system.  Recently, there has been increased alignment of OUD care across the criminal-legal system with the patient-centered American Society of Addiction Medicine guidelines. Whether by choice or through legislation, carceral facilities are increasingly offering FDA-approved medications for OUD (MOUD), which […]