Sean Murphy

On September 29, 2025, the Justice Community Overdose Innovation Network (JCOIN) kicked off Phase II of its new five-year cycle that represents an estimated $33 million in research investments in 2025. Awarded by the National Institute on Drug Abuse (NIDA) as part of the NIH HEAL Initiative, the investments help establish clinical research hubs and […]

Buprenorphine, when prescribed in the emergency department (ED), increases the chances for treatment engagement and retention among patients with opioid use disorder (OUD). The patient uptake and clinical administration of ED-initiated buprenorphine for OUD, however, has been slow despite evidence of its effectiveness. Implementation facilitation (IF), a strategy that leverages external facilitators and a local […]

Lead author Hana Zwick, a research data analyst at the Syndemics Lab, and colleagues published a new simulation modeling study in JAMA Network Open to understand the public health and economic outcomes of strategies that arrest, disperse, or house people who live in encampments and experience high-risk opioid use compared to the encampment status quo. […]

In the last eight years, emergency departments (EDs) have seen an influx of visits related to opioid use disorder (OUD). For the same reason, researchers have been citing EDs to be a critical setting and reachable moment for initiating OUD medications, the gold standard of care. Buprenorphine is advantageous as a low-barrier OUD treatment compared […]

Substance use disorders (SUD), and especially opioid use disorder (OUD), are prevalent within the criminal-legal system.  Recently, there has been increased alignment of OUD care across the criminal-legal system with the patient-centered American Society of Addiction Medicine guidelines. Whether by choice or through legislation, carceral facilities are increasingly offering FDA-approved medications for OUD (MOUD), which […]

In this systematic literature review published in Value in Health, CHERISH Research Affiliates Czarina Behrends and Ahmed Bayoumi, CHERISH staff members Jared Leff, Jazmine Li, and Erminia Fardone, CHERISH investigators Kathryn McCollister, Sean M. Murphy, and Bruce Schackman, and former NIDA summer intern, Weston Lowry, analyzed 16 studies that summarized and identified gaps of economic […]

The 4th Annual NIH Helping to End Addiction Long-Term (HEAL) Initiative Investigator Meeting took place on February 22, 2023. HEAL-funded investigators and key stakeholders gathered in Bethesda, MD, to share research findings and identify new opportunities for pain and opioid use disorder research. HEAL Director Dr. Rebecca Baker also presented the inaugural NIH HEAL Initiative Director’s Awards for […]

Despite evidence that medications for opioid use disorder (MOUD), namely methadone, buprenorphine, and naltrexone, provided at the point of incarceration improve the well-being of the individual and the public, financial and administrative limitations in jail/prison healthcare often serve as barriers to this recommended first-line treatment for OUD. In fact, evidence indicates that more than 80% […]

Conducting an economic evaluation alongside a randomized clinical trial provides valuable information for clinicians, insurers, and policy stakeholders. Integrating an economic evaluation within a trial provides researchers the opportunity to collect patient-level data at multiple time points on both cost and effectiveness outcomes, and to measure the comparative impact of treatments on these outcomes while […]

Naltrexone and buprenorphine are two effective medications for opioid use disorder (OUD). Naltrexone, which is typically given as a monthly extended-release injection (XR-NTX), and daily oral buprenorphine, which is typically combined with naloxone (BUP-NX), are prescribed in outpatient or office-based medical settings. XR-NTX patients, however, need to complete detoxification before starting treatment. Results from a […]

In this systematic review, researchers affiliated with the Center for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV (CHERISH) including CHERISH staff Erica Onuoha and Jared Leff; CHERISH investigators Bruce R. Schackman, Kathryn E. McCollister, and Sean M. Murphy; and CHERISH Advisory Board member Daniel Polsky, identified new studies supporting buprenorphine and methadone as economically advantageous medications for […]

Medications for opioid use disorder (MOUD) are evidence-based treatments that help people reduce or stop using opioids. However, high discontinuation rates of MOUD pose a barrier to reducing opioid-related overdoses. Extended-release buprenorphine (XR-BUP) is a relatively new MOUD, approved in late 2017, that has the potential to increase retention because of its monthly dosing schedule. Currently, there is […]