This training module continues to describe health-related quality of life assessments as a common measure of effectiveness in economic evaluations. In this module we introduce algorithm-based quality of life measurement tools commonly used in economic evaluations. We describe the important considerations when selecting a quality of life assessment. We then explain how these quality of life measures are used to calculate Quality-Adjusted of Life Years (QALYs), which are a common measure of effectiveness for economic evaluations. At the end of this module, participants should be able to describe the differences between preference based, non-preference based, generic, and disease specific quality of life measurement tools, and understand how these utility measures are used to calculate quality-adjusted life years as a measure of effectiveness for economic evaluations.