Research Highlight

Publications funded by or feature contributions from CHERISH.

May 28, 2020 Research Highlight

After Opioid Overdose Emergency, Few Patients Receive Timely Follow-up

An opioid overdose is significantly more than an isolated event. Patients who present to the emergency department (ED) with overdose have a 6 percent risk of dying in the following year. As with other high-risk acute conditions, we expect patients who survive overdose to receive evidence-based treatment after leaving the hospital. Whether the overdose was due to prescription […]

May 12, 2020 Research Highlight

COVID-19 Can Change The Way We Respond To The Opioid Crisis – For The Better

The Coronavirus (COVID-19) pandemic has brought unprecedented challenges in healthcare delivery to people who use drugs. However, it may also have provided impetus to precipitate innovative changes in providing opioid overdose prevention, syringe services, and medication for opioid use disorder (MOUD) to this vulnerable population. In a new Viewpoint in Psychiatric Services, CHERISH Research Affiliate Yuhua Bao from […]

May 6, 2020 Research Highlight

Simulation Modeling Presents Opportunities To Support The Public Health Response To The Opioid Crisis In North America

Although there are several evidence-based cost-effective interventions for people with opioid use disorder (OUD), they are underutilized. Questions remain regarding intervention selection, and cost of service delivery. Simulation modeling offers an opportunity to support decision making to address the syndemic of opioid overdose, HIV, and hepatitis C (HCV). In an article recently published in the International Journal […]

March 17, 2020 Research Highlight

Optimizing HIV Prevention in Six US Cities: An Economic Model

In 2019, the United States launched the effort to End the HIV Epidemic by reducing new infections by 75% within 5 years and by 90% within 10 years. This national strategy comes with some new funding for the Centers of Disease Control and Prevention (CDC), the Health Resources and Services Administration (HRSA), and the Ryan White HIV/AIDS […]

February 27, 2020 Research Highlight

Overdose and Re-hospitalization Rates Following Endocarditis Are Lower for Patients Receiving Medications for Opioid Use Disorder

The proportion of hospital admissions for endocarditis attributable to injection drug use increased from 7% in 2000 to 12% in 2013. Endocarditis is an infection in the lining of the heart chambers and valves that can be contracted through shared injection equipment. Rates of endocarditis are disproportionately affecting young people who inject drugs (PWID), which has […]

January 29, 2020 Research Highlight

Will Eliminating Waiver Requirements Improve Access to Buprenorphine for Treating Opioid Use Disorder? Evidence From Increasing the Patient Treatment Cap

The Drug Addiction Treatment Act of 2000 (DATA 2000) permits qualified physicians to obtain a waiver to treat patients with opioid use disorder (OUD) with buprenorphine in office-based practices. In 2016, 47% of all US counties and 72% of rural counties lacked a buprenorphine waivered physician. That year, the Comprehensive Addiction and Recovery Act extended buprenorphine prescribing […]

January 6, 2020 Research Highlight

Hospital Financial Incentives to Improve Care After Opioid Overdose

Early analysis of Pennsylvania’s program Two patients are treated for opioid overdose at two different hospitals, just a few miles apart. The first hospital provides life-saving treatment to reverse the overdose and watches the patient for an hour, discharging them when deemed “medically stable.” The second hospital also provides life-saving treatment but then offers counseling, […]

December 9, 2019 Profile Feature

Methodology Consultation Success Story: Dr. Ashish Premkumar

The incidence of neonatal abstinence syndrome (NAS), also known as neonatal withdrawal syndrome, increased nationally from 3.4 per 1000 hospital births in 2009 to 5.8 in 2012. Recent estimates of NAS cost $1.5 billion dollars with the majority of the financial burden falling to state Medicaid programs. However, pregnancy offers a unique opportunity for women with […]

October 31, 2019 Research Highlight

USPSTF and CDC Recommend Expanded HCV Testing for All US Adults

The US Preventive Services Task Force (USPSTF) released a draft recommendation for hepatitis C (HCV) antibody and RNA screening in all adults ages 18 to 79. This is a departure from their current 2013 recommendation of risk-based screening, including people who inject drugs (PWID), and one-time screening in baby boomers born between 1945 and 1965.  The recommendation […]

September 6, 2019 Research Highlight

Increased number of children entering the foster care due to parental drug use

In a recent study published in JAMA Pediatrics, CHERISH Pilot Grant Recipient Angelica Meinhofer examined national trends in foster care entries attributable to parental drug use between 2000 and 2017. There were approximately 5 million foster care entries between 2000 and 2017, 23.38% percent of which were attributable to parental drug use. Moreover, the number of […]

July 16, 2019 Research Highlight

Care Integration of Hepatitis C and Opioid Use Disorder Treatment is Cost-Effective and Improves Health Outcomes

People who inject drugs (PWID) often become infected with HIV and hepatitis C virus (HCV). While hepatitis C can be successfully treated with medication, care is often fragmented and rarely integrated within one program or setting. Two recent studies by CHERISH researchers modeled economic and health outcomes for PWID and found evidence of synergistic benefits […]

July 10, 2019 Research Highlight

No Safe Dose for That First Opioid Prescription

LDI Senior Fellows Zack Meisel, Benjamin Sun, and colleagues have a striking and sobering chart in a recent Annals of Emergency Medicine article on initial opioid prescriptions in the emergency department. They tracked how many “opioid-naïve” patients (i.e., those without a record of opioid use in the previous year) had persistent or high-risk opioid prescription use in the subsequent […]

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