Research Highlights

October 16, 2022 Research Highlights

Engaging with People with Lived Experiences in OUD Modeling Research

Drug overdose deaths continue to rise in the United States and Canada, with the risks for greater opioid use sharply increasing in Mexico. As modelers, we know simulation modeling is a valuable tool that can inform policies and interventions to prevent overdose deaths and reduce related harms including drug overdose, HIV, and hepatitis C virus […]

October 3, 2022 Research Highlights

Prevalence of HIV Preexposure Prophylaxis Prescribing Among Persons with Commercial Insurance and Likely Injection Drug Use

The United States has made important strides to reduce the incidence and negative outcomes of HIV, including increasing the availability of effective treatment and prevention in the form of pre-exposure prophylaxis (PrEP). While the incidence of new HIV infections fell significantly from 130,000 in 1985, progress has stalled at approximately 39,000 new infections per year […]

September 23, 2022 Research Highlights

Paying Patients Can Improve Engagement in Mental Health Treatment

Financial incentives are known to increase patient engagement in a wide range of health programs, including programs for maintaining abstinence from substances, attending vaccination and screening appointments, and increasing physical activity. However, they have rarely been used for mental health care beyond treating substance use disorders. Showing up and being involved in mental health treatment […]

August 1, 2022 Research Highlights

Cost-effectiveness of Extended-release Injectable Naltrexone among Incarcerated Persons with Opioid Use Disorder Before Release from Prison Versus After Release

Compared to the general population, individuals with opioid use disorder (OUD) who are involved with the criminal-legal system have a much higher risk of a fatal overdose after release from incarceration. Yet, stigma, costs, and preferences for non-narcotic treatments in criminal-legal settings have stalled the implementation of life-saving treatment within the criminal-legal system. Extended-release naltrexone […]

June 29, 2022 Research Highlights

Evidence for Supportive Prenatal Substance Use Policies

Increased prevalence of illicit substance use during pregnancy in the past decade has renewed national attention to prenatal substance use policies (PSUPs). Currently, there are punitive policies that criminalize drug use during pregnancy or define prenatal substance use as child maltreatment in child welfare statutes. If newborns are found to have prenatal exposure to substances […]

March 25, 2022 Research Highlights

Providing Naloxone in the Emergency Department Can Save Lives

Overdose deaths continue to be a national tragedy. More than 800,000 Americans died from an overdose between 1999-2019, and the annual rate of overdoses has increased dramatically during the pandemic, according to the latest data from the Centers for Disease Control and Prevention. Roughly 7 in 10 current overdose deaths involve opioids, which means that […]

March 3, 2022 Research Highlights

Cost of Hepatitis C Care Facilitation for HIV/Hepatitis C Co-infected People Who Use Drugs

The development of direct-acting antivirals transformed hepatitis C virus (HCV) therapy, allowing patients to experience fewer side effects and non-specialist providers to prescribe HCV treatment with more ease. Despite these advances, existing social and structural barriers, such as stigma and accessibility of medical care, restrict access to effective HCV treatment for people who use drugs […]

December 20, 2021 Research Highlights

Targeting Emergency Department Resources to Address the Opioid Epidemic

In a new study in the American Journal of Emergency Medicine, my colleagues and I estimate the number and distribution of emergency visits for opioid use disorder (OUD) across the country. We found that nearly 2/3 of all emergency visits for OUD occurred in 25% of EDs nationwide. Why is this important? Patients with OUD come to the […]

November 11, 2021 Research Highlights

The Impact of Recreational Cannabis Laws and Cannabis Use Disorder Among Pregnant Patients

To date, the American College of Obstetricians and Gynecologists advises pregnant patients not to use cannabis because of the increased risks of health complications to the pregnant individual and the newborn. However, as states expand access to recreational or medical cannabis, there is growing evidence of increased cannabis use and positive perceptions of cannabis among pregnant patients. […]

October 8, 2021 Research Highlights

Ending HIV in the United States Will Require a Substantial Financial Commitment

“What will it take to end HIV in the United States?” is a pressing question posed by public health officials, researchers, and policymakers alike. Population Data & Modeling Core Director Benjamin Linas seeks to answer that question by amplifying notable results from a simulation modeling study published by researchers at Johns Hopkins. In an editorial issued in the Annals of […]

September 27, 2021 Research Highlights

Weighing the Costs and Benefits of Initiating Extended-release Injectable Naltrexone Compared to Buprenorphine-naloxone

Naltrexone and buprenorphine are two effective medications for opioid use disorder (OUD). Naltrexone, which is typically given as a monthly extended-release injection (XR-NTX), and daily oral buprenorphine, which is typically combined with naloxone (BUP-NX), are prescribed in outpatient or office-based medical settings. XR-NTX patients, however, need to complete detoxification before starting treatment. Results from a […]

August 12, 2021 Research Highlights

Patient Preferences Do Not Explain Racial Disparities in Opioid Prescribing

Why are Black patients less likely than white patients to be prescribed opioids for acute pain in the emergency department (ED)? While many theories have been put forward (ranging from racial differences in patients’ pain management preferences to providers’ false beliefs in biological differences between racial groups), the specific mechanisms underpinning these disparities are unclear. […]

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