Research Highlights

April 17, 2024 Research Highlights

7 Ways to Improve an Already Effective Treatment for Stimulant Use Disorder

The opioid epidemic has been one of the most pressing and challenging issues that the U.S. has faced in recent decades, with countless lives lost to this devastating crisis. Now, stimulant-related overdoses are among the next big drug-related concerns, with recent studies showing that the mortality rate linked to stimulant use in the U.S. has […]

April 8, 2024 Research Highlights

Economic Evaluations of Establishing Opioid Overdose Prevention Centers in 12 North American Cities: A Systematic Review

In this systematic literature review published in Value in Health, CHERISH Research Affiliates Czarina Behrends and Ahmed Bayoumi, CHERISH staff members Jared Leff, Jazmine Li, and Erminia Fardone, CHERISH investigators Kathryn McCollister, Sean M. Murphy, and Bruce Schackman, and former NIDA summer intern, Weston Lowry, analyzed 16 studies that summarized and identified gaps of economic […]

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April 2, 2024 Research Highlights

New Study Reveals Preventable-Suicide Risk Profiles

Individuals with physical health concerns made up the largest and fastest growing of five subgroups of individuals who died by suicide n the United States over roughly twenty years, according to an analysis led by Weill Cornell Medicine in collaboration with Columbia University, UC Berkeley School of Public Health, the University of Hong Kong and […]

March 8, 2024 Research Highlights

Surgeons Are Closer to Predicting Which Patients Need Post-Surgery Opioids—and Which Ones Don’t

Opioids are routinely prescribed to patients after a surgery—whether they use them or not. A new study, led by LDI Senior Fellow Anish Agarwal will help tailor prescribing so patients get the right amount of opioid medications; not too little and not too much. Unused opioids are a particular problem. Opioid misuse can start when extra tablets […]

March 8, 2024 Research Highlights

Chart of the Day: Rise in Patients with Opioid Use Disorder Leaving Hospital Prematurely

LDI Senior and Associate Fellows Ashish Thakrar, Margaret (Maggie) Lowenstein, Ryan Greysen, and M. Kit Delgado found that more people with opioid use disorder are leaving the hospital prematurely (or before medically advised), compared to marginal increases for individuals admitted for other reasons. In the study, “Trends in Before Medically Advised Discharges for Patients with Opioid Use Disorder, 2016-2020,” […]

August 23, 2023 Policy Watch

Many State Medicaid Programs Still Require Prior Authorization for Buprenorphine Treatment for Opioid Use Disorder

The opioid epidemic has been an ongoing public health crisis in the United States, claiming countless lives and devastating communities. Buprenorphine, a highly effective medication for the treatment of opioid use disorders, holds the potential to save lives. However, a significant hurdle exists in the form of prior authorization requirements, which are associated with lower access to […]

August 4, 2023 Research Highlights

Initiation of Hepatitis C Treatment Low Among Medicaid Recipients

While there are highly effective treatments for the hepatitis C virus (HCV), only 1 in 5 Medicaid enrollees diagnosed with HCV started treatment, according to a retrospective study led by researchers at Weill Cornell Medicine and Cornell University’s Ithaca campus. The findings revealed that treatment uptake rates were even lower among people under 30, women, […]

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July 11, 2023 Research Highlights

Economic benefits of substance use disorder treatment: A systematic literature review of economic evaluation studies from 2003 to 2021

The economic burden of substance use disorder (SUD) is significant. It encompasses clinical and societal costs such as health care and social services, criminal justice resources, loss of productivity, and premature mortality, and is estimated to cost more than $700 billion per year in the United States. To understand the gravity of these economic costs, […]

February 8, 2023 Research Highlights

Budget Impact Tool for the Incorporation of Medications for Opioid Use Disorder into Jail/Prison Facilities

Despite evidence that medications for opioid use disorder (MOUD), namely methadone, buprenorphine, and naltrexone, provided at the point of incarceration improve the well-being of the individual and the public, financial and administrative limitations in jail/prison healthcare often serve as barriers to this recommended first-line treatment for OUD. In fact, evidence indicates that more than 80% […]

November 16, 2022 Research Highlights

Addressing Statistical Issues Encountered in Conducting Prospective Economic Evaluations Alongside Clinical Trials

Conducting an economic evaluation alongside a randomized clinical trial provides valuable information for clinicians, insurers, and policy stakeholders. Integrating an economic evaluation within a trial provides researchers the opportunity to collect patient-level data at multiple time points on both cost and effectiveness outcomes, and to measure the comparative impact of treatments on these outcomes while […]

October 24, 2022 Policy Watch

A Catch-Up on Promising Efforts to Mitigate the Opioid Crisis

For the last 20 years or so, the U.S. has seen a significant increase in opioid and drug overdoses overall. And while there was a slight leveling before the pandemic, “we’ve seen huge increases since COVID-19,” said Margaret Lowenstein, an LDI Senior Fellow, addiction medicine physician, and an Assistant Professor of Medicine at the Perelman School of […]

October 16, 2022 Research Highlights

Engaging with People with Lived Experiences in OUD Modeling Research

Drug overdose deaths continue to rise in the United States and Canada, with the risks for greater opioid use sharply increasing in Mexico. As modelers, we know simulation modeling is a valuable tool that can inform policies and interventions to prevent overdose deaths and reduce related harms including drug overdose, HIV, and hepatitis C virus […]

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